Symbol
Name
ID

Crebbp
CREB binding protein
MGI:1098280

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Leukemia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Acute myeloid leukemia	Lymphoma	Accessory spleen	Polysplenia
Disease(s) Associated with CREBBP	Leukemia	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Acute myeloid leukemia	Lymphoma	Accessory spleen	Polysplenia
acute lymphoblastic leukemia
acute myeloid leukemia
Rubinstein-Taybi syndrome

Mouse Phenotypes

small thymus

decreased thymocyte number

enlarged spleen

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

decreased common myeloid progenitor cell number

decreased double-positive T cell number

increased double-positive T cell number

extramedullary hematopoiesis

anemia

impaired hematopoiesis

increased bone marrow cell number

abnormal megakaryocyte morphology

increased megakaryocyte cell number

abnormal granulocyte morphology

increased granulocyte number

decreased B cell number

absent pre-B cells

decreased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased lymphocyte cell number

decreased hematopoietic stem cell number

abnormal leukocyte morphology

Availability

Mouse Genotype

Crebbp^{Gt(U-San)112Imeg}/Crebbp^{Gt(U-San)112Imeg}

Crebbp^tm1Pkb/Crebbp^tm1Pkb

Crebbp^tm1Sis/Crebbp^tm1Sis

Crebbp^tm1Dli/Crebbp⁺

Crebbp^tm1Jvd/Crebbp^tm1Jvd
Tg(MMTV-cre)4Mam/0 (conditional)

Crebbp^tm1Jvd/Crebbp^tm1Jvd
Tg(Lck-cre)548Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23